Britain is set to formally file for divorce from the European Union Wednesday says Theresa May(Photo: Associated Press)

LONDON (AP) — Britain is set to formally file for divorce from the European Union Wednesday, ending a 44-year relationship, enacting the decision made by U.K. voters in a referendum nine months ago and launching both Britain and the bloc into uncharted territory.

Britain’s Prime Minister Theresa May, sitting below a painting of Britain’s first Prime Minister Robert Walpole, signs the official letter to European Council President Donald Tusk, in 10 Downing Street, London, Tuesday March 28, 2017, invoking Article 50 of the bloc’s key treaty, the formal start of exit negotiations. Britons voted in June to leave the bloc after four decades of membership. (Christopher Furlong/Pool Photo via AP)

Invoked Article Fifty

Prime Minister Theresa May is due to tell House of Commons at lunchtime that she has invoked Article 50 of the EU’s key treaty, the trigger for a two-year countdown to Britain’s exit. Just before May’s statement, scheduled for 1130 GMT (7:30 a.m. EDT), Britain’s EU envoy, Tim Barrow, will hand-deliver a letter from May to EU Council President Donald Tusk in Brussels.

Photos were released of May signing the letter late Tuesday in the Cabinet room at 10 Downing St., under a portrait of Britain’s first prime minister, Robert Walpole. May’s office said she will tell lawmakers that the U.K. is embarking on a «momentous journey» and should unite to forge a «global Britain.»

«It is my fierce determination to get the right deal for every single person in this country,» she will say. Britain’s Treasury chief, Philip Hammond, said that triggering Brexit was «a pivotal moment for Britain,» but denied the country was taking a leap in the dark.

«We all have the same agenda. We are all seeking to get the best possible deal for Britain,» he told the BBC. Hammond said he was optimistic of forging «a relationship that will strengthen the U.K. and will strengthen the European Union as well.»

Less Certain

Gus O’Donnell, the U.K.’s former top civil servant, was less certain. «We are in a plane being flown by members of the EU and we’re about to jump out and we’ve got a parachute that was designed by the people flying the plane and they designed it in a way to deter anybody else jumping out,» he said.

Britain and the EU have two years to unpick a tapestry of rules, regulations and agreements stitched over more than four decades since Britain joined what was then the European Economic Community in 1973.

EU officials are due to circulate draft negotiating guidelines within days, and bloc leaders — minus May — will meet April 29 to adopt a common position. Britain says it’s not turning its back on its neighbors and wants to remain friends. May has said that the U.K. will become «stronger, fairer, more united and more outward-looking» and will seek «a new, deep and special partnership with the European Union.»

But many British businesses fear the impact of leaving the EU’s vast single market of some 500 million people. Senior British officials say they are confident of striking a close new free-trade relationship with the bloc — but a successful outcome to the complex and emotionally fraught negotiations is far from certain.

Brexit has profound implications for Britain’s economy, society and even unity. The divisive decision to leave the EU has given new impetus to the drive for Scottish independence, and undermined the foundations of Northern Ireland’s peace settlement.

It’s also a major blow to the EU, after decades of expansion, to lose one of its largest members. Anti-EU populists including French far-right leader Marine Le Pen hope the impulses that drove Britain to turn its back on the EU will be repeated across the continent. Associated Press writer Danica Kirka contributed to this story from Associated Press.

Prime Minister Theresa May with prime minister Carwyn Jones from Wales(Photo: Associated Press)

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